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KMID : 1143420200130412948
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Public Health Weekly Report
2020 Volume.13 No. 41 p.2948 ~ p.2955
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Analysis of Genotype and Drug Resistance of Human Immunodeficiency Virus in Korea from 2018-2019
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Park Kye-Ryeong
Sim Hyo-Jeong
Wang Jin-Sook
Han Myung-Guk
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Abstract
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Genetic analysis for Human immunodeficiency virus (HIV) from early-stage HIV infected person, collected at 2018-2019 in Korea, was conducted on distribution of genotype and drug resistance mutation. HIV-1 Korean subtype B was identified as a major genotype (70.3%), showing an 8.9% decrease from the average distribution over a seven-year period. In addition, HIV-1 subtypes A1, C and various circulating recombinant forms (CRF) 56_CPX (7.9%), 01_AE (10.8%), 02_AG (0.7%), and 07_BC (3.6%) were confirmed. Mutations that reduce the sensitivity of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in antiretroviral drugs were identified (17.7% in 2018 and 17.9% in 2019) and showed an increase from 2017. These results will be useful in developing guidelines for identifying HIV/AIDS strains and using therapeutic agents.
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KEYWORD
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Human Immunodeficiency Virus (HIV), Subtypes, Drug resistance, AIDS
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